Devastating blow to the Prime Minister as Purnell has quit the Cabinet, picking up a lot of media plaudits in the process. If he is followed in the next few hours and days by more resignations, then the move will be complete and Gordon Brown's time will be finished.
The rumours are that Alasdair Darling is furious about his treatment and if he were to quit the blow would be completely fatal. With terrible electoral results likely to be in the offing, it is going to be a very brutal period ahead.
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